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He used his celebrity status to establish Pasteur Institutes across Europe and Asia, and his nephew, Adrien Loir, travelled to Australia in 1888 to try to introduce the vaccine to combat anthrax in New South Wales. Patients with severe depressive symptoms should seek immediate medical evaluation to assess the possibility that the symptoms are related to COMPLERA, and if so, to determine whether the risks of continued therapy outweigh the benefits. Caution should be paid to verify the efficacy of edaravone in ALS patients with special reference to severity of disease as I mentioned in the second paragraph Teratogenicity and embryo-lethality occurred in animals administered leflunomide at doses lower than the human exposure level.